摘要 |
This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I): wherein substitutions at LG'', PG, A, G, R<SUB>1 </SUB>and R<SUB>4 </SUB>are set forth in the specification. |