| 摘要 |
This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC-(CRR)<SUB>m</SUB>-COOH, wherein: m=2, 3 or 4; Z is OH or NH<SUB>2</SUB>; one R in the compound is from the group consisting of SO<SUB>3</SUB>H, OSO<SUB>3</SUB>H, CH<SUB>2</SUB>-SO<SUB>3</SUB>H, CH<SUB>2</SUB>-OSO<SUB>3</SUB>H, and NHSO<SUB>3</SUB>H, and the remaining Rs are H or NH<SUB>2</SUB>, for inhibition of osteoclastogenesis.
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