摘要 |
This invention provides a compound, or its possible salt, having the formula, wherein: R<SUP>e </SUP>and 'R<SUP>e </SUP>are OH, optionally independently etherified or esterified; Z is -CH<SUB>2</SUB>CH<SUB>2</SUB>- or -C(R<SUP>4</SUP>,R<SUP>5</SUP>)-, wherein R<SUP>4 </SUP>and R<SUP>5 </SUP>are independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; R<SUP>1 </SUP>is H, halogen, CF<SUB>3</SUB>, or (1C-4C)alkyl; R<SUP>2 </SUP>and R<SUP>3 </SUP>are independently H, halogen, -CF<SUB>3</SUB>, -OCF<SUB>3</SUB>, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, -O(CH<SUB>2</SUB>)<SUB>m</SUB>X, wherein X is halogen or phenyl and m=2-4; -O(CH<SUB>2</SUB>)<SUB>m</SUB>NR<SUB>a</SUB>R<SUB>b</SUB>, -S(CH<SUB>2</SUB>)<SUB>m</SUB>NR<SUB>a</SUB>R<SUB>b </SUB>or -(CH<SUB>2</SUB>)<SUB>m</SUB>NR<SUB>a</SUB>R<SUB>b</SUB>, wherein m=2-4 and wherein R<SUB>a</SUB>, R<SUB>b </SUB>are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, -CF<SUB>3</SUB>, -OCF<SUB>3</SUB>, -CN, -NO<SUB>2</SUB>, -OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or R<SUB>a </SUB>and R<SUB>b </SUB>form a 3-8 membered ring structure, optionally substituted with halogen, -CF<SUB>3</SUB>, -OCF<SUB>3</SUB>, -CN, -NO<SUB>2</SUB>, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl. |