发明名称 |
Normal;heading 1;heading 2;GLUCAGON-LIKE PEPTIDE 1 HETEROLOGOUS FUSION PROTEIN FOR THE PREPARATION OF A MEDICINE FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS |
摘要 |
The present invention relates heterologous fusion protein comprising a first polypeptide fused to a second polypeptide wherein the first polypeptide is a GLP-1 compound (glucagon-like peptide 1) and the second polypeptide is selected from the group consisting of a) human albumin; b) human albumin analogs; and c) fragments of human albumin. These proteins have the effect of extending the in vivo half-life of the peptides. The invention relates as well to pharmaceutical composition comprising these fusion proteins and use of the heterologous fusion protein for the preparation of a medicine for treatment of non-insulin dependent diabetes mellitus as well as a variety of other conditions. |
申请公布号 |
UA81897(C2) |
申请公布日期 |
2008.02.25 |
申请号 |
UA20030065280 |
申请日期 |
2001.11.29 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
MICANOVIC RADMILLA;TSCHANG SHEN-HUNG RAINBOW |
分类号 |
C07K14/435;C12N15/02;A61K38/00;A61K38/26;A61K47/42;A61P3/04;A61P3/10;C07H21/04;C07K14/605;C07K14/76;C07K14/765;C07K16/18;C07K19/00;C12N5/10;C12N15/62;C12P21/02 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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