O-ACETYLTRANSFERASE FROM NEISSERIA MENINGITIDIS, COMPOSITIONS AND METHODS

摘要

Provided are recombinant DNA molecules that do not occur in nature encoding a Lot3 O-acetyltransferase, vectors that direct expression of a Lot O- acetyltransferase, recombinant host cells which express a Lot3 O- acetyltransferase, methods for recombinant production of a Lot3 O-acetyltransferase, methods for acetylating lipooligosaccharides, especially those of a Neisseria meningitidis using a recombinant Lot O-acetyltransferase, and immunogenic compositions comprising the acetylated Iipooligosaccharide.