| 摘要 |
<p>The invention can be used in physiology, in pharmacology for developing novel medicinal preparations and in medicine. The invention relates to the synthesis of peptides of general formula (I), peptides of general formula A-B-Tyr-Pro (DPro, dHPro, DdHPro, DLdhPro, Hyp)-C-X, wherein: A- O, -Ala, -Asp, -Glu, -Phe, -His, -Ile, Lys, -Leu, -Met, -Pro, -Arg, -Ser, -Thr, -Val, -Trp,-Tyr; B- O, -Ala, -Asp, -Glu, -Phe, -His, -Ile, Lys, -Leu, -Met, -Pro, -Arg, -Ser, -Thr, -Val, -Trp,-Tyr; C- O, -Ala, -Asp, -Glu, -Phe, -His, -Ile, Lys, -Leu, -Met, -Pro, -Arg, -Ser, -Thr, -Val, -Trp,-Tyr; X - OH, -OCH<SUP>3</SUP>, -NH<SUB>2</SUB>, and the use threof for developing novel medicinal preparations exhibiting analgetic activity.</p> |
| 申请人 |
INSTITUT MOLEKULYARNOI GENETIKI ROSSIISKOI AKADEMII NAUK (IMG RAN);GOSUDARSTVENNOE UCHREZHDENIE NAUCHNO-ISSLEDOVATELSKY INSTITUT FARMAKOLOGII IMENI V.V. ZAKUSOVA ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK (GU NII FARMAKOLOGII IMENI V.V. ZAKUSOVA RAMN);ALFEEVA, LYUDMILA YURIEVNA;ANDREEVA, LYUDMILA ALEXANDROVNA;VORONINA, TATYANA ALEXANDROVNA;GUZEVATYKH, LYUDMILA SERGEEVNA;EMELYANOVA, TATYANA GEORGIEVNA;MYASOEDOV, NIKOLAY FEDOROVICH;SEREDENIN, SERGEI BORISOVICH |
发明人 |
ALFEEVA, LYUDMILA YURIEVNA;ANDREEVA, LYUDMILA ALEXANDROVNA;VORONINA, TATYANA ALEXANDROVNA;GUZEVATYKH, LYUDMILA SERGEEVNA;EMELYANOVA, TATYANA GEORGIEVNA;MYASOEDOV, NIKOLAY FEDOROVICH;SEREDENIN, SERGEI BORISOVICH |
