| 摘要 |
<p>The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3' untranslated region (3'-UTR) comprising a .DEL TA.30 mutation that removes the TL-2 homologous structure in each of the den gue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the .DELTA .30 mutation deleted from the 3'-UTR that removes sequence in the 5' directi on as far as the 5' boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3'-UTR of a dengue virus of a first serotype with the 3'-UTR of a dengue virus of a seco nd serotype, optionally containing the .DELTA.30 mutation and nucleotides ad ditional to the .DELTA.30 mutation deleted from the 3'-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of produci ng a dengue virus or chimeric dengue virus.</p> |
