HUMAN-POWERED DRY POWDER INHALER AND DRY POWDER INHALER COMPOSITIONS
摘要
In one embodiment, a human-powered dry powder inhaler comprises a human- powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged from the human-powered compressible component to provide an aerosol of a dry powder pharmaceutical formulation in the reservoir, the reservoir including an outlet valve; and a receiving mask in communication with the outlet valve and operable to receive an aerosol of dry powder from the reservoir and to deliver the aerosol to at least a mouth or nose of a patient. In another embodiment, the inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet of a polymeric pressure release valve at a pressure of about 1-40 psi; and a receiving mask in communication with the outlet of the compressible component and operable to deliver an aerosol of dry powder to at least a mouth or nose of a patient. Methods for delivery of a dry powder pharmaceutical formulation to a patient are conducted in the absence of electrical power and circuitry and pre-pressurized propellant gas. Suitable dry powder pharmaceutical formulations may include myo-inositol and/or maltodextrin as a carrier and active ingredients such as vaccines or siRNA.
申请公布号
WO2008021451(A2)
申请公布日期
2008.02.21
申请号
WO2007US18176
申请日期
2007.08.14
申请人
AKTIV-DRY LLC;SIEVERS, ROBERT, E.;BEST, JESSICA, A.;CAPE, STEPHEN, P.
发明人
SIEVERS, ROBERT, E.;BEST, JESSICA, A.;CAPE, STEPHEN, P.