| 摘要 |
Tissue protective compounds comprise the tetrapeptide structure A - B- C- D wherein each hydrogen of the N-terminus NH2 of amino acid residue A may i ndependently optionally be replaced by C1-S alkyl or C1-S acyl, A - is an ar omatic amino acid residue wherein the aromatic ring may optionally be substi tuted with one or more nitro group, B - is a diamino acid residue wherein th e side chain amino group is substituted with C1-S acyl, C1-S alkyl, -B'-Ci-s acyl or -B'-Ci-s alkyl, wherein B' is an amino acid residue which may optio nally be substituted with one or more nitro group, C - is GIy wherein the pe ptide N-H may optionally be changed to N-methyl, D - is Phe which is substit uted on the aromatic ring with at least one nitro group and optionally furth er substituted on the aromatic ring with one or more group independently sel ected from nitro, fluoro, chloro, bromo, iodo, CF3 or CN, wherein the peptid e N-H may optionally be changed to N-methyl, and the C-terminus C=O of amino acid residue D is substituted with NH2, NHC1-5 alkyl, NH-NH2, NH-NHC1-5 alk yl, or 0-C1-S alkyl, or the C-terminus is COOH or CH2OH, or a pharmaceutical ly acceptable salt thereof. |
