发明名称 |
GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF |
摘要 |
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and variants thereof). These compounds are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperproliferative disorders. |
申请公布号 |
WO2007127457(A3) |
申请公布日期 |
2008.02.21 |
申请号 |
WO2007US10389 |
申请日期 |
2007.04.30 |
申请人 |
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;BOWERS, CYRIL, Y.;TANNENBAUM, GLORIA, S.;COY, DAVID, H.;HOCART, SIMON, J. |
发明人 |
BOWERS, CYRIL, Y.;TANNENBAUM, GLORIA, S.;COY, DAVID, H.;HOCART, SIMON, J. |
分类号 |
A61K38/08;C07C15/00;C07C229/00;C07K7/06 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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地址 |
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