FORMULATION AND METHOD FOR ENHANCEMENT OF GASTROINTESTINAL ABSORPTION OF PHARMACEUTICAL AGENTS
摘要
The present invention relates to a method of enhancing absorption of a pharmaceutical agent by administering the agent in combination with an inhibitor of BCRP/ABCG2 wherein the amount of the inhibitor is about the critical micelle concentration of the inhibitor or less than the critical micelle concentration. The invention also relates to a formulation suitable for use to enhance absorption of a pharmaceutical agent. The pharmaceutical agent can be a chemotherapeutic agent. The invention also relates to capsules containing the formulation.
申请公布号
WO2007027560(A8)
申请公布日期
2008.02.21
申请号
WO2006US33423
申请日期
2006.08.28
申请人
WARNER-LAMBERT COMPANY LLC;SUGIYAMA, YUICHI;MORISHITA, MARIKO;BENAMEUR, HASSAN;DAUMESNIL, ROLAND
发明人
SUGIYAMA, YUICHI;MORISHITA, MARIKO;BENAMEUR, HASSAN;DAUMESNIL, ROLAND