USE OF METHYLENE BLUE FOR TREATMENT OF RETINAL DAMAGE AND PROTECTION OF RETINA

摘要

A formulation comprising methylene blue is provided to be effective for inhibiting retinotoxic effect induced by the increase of cGMP, specifically inhibiting the retinotoxic effect by theophylline. A formulation for treating retinal damage and protecting retina comprises methylene blue as an effective ingredient, wherein the retinal damage is caused by cyclic GMP(cGMP) increased by inhibiting phosphodiesterase(PDE) and 1-2 mg/kg of the methylene blue is administered into the retina through oral administration, instillation or injection.