| 摘要 |
PROBLEM TO BE SOLVED: To provide a formulation design capable of maintaining tablet hardness with no practical problem together with rapid disintegration of tablets even if made into a tablet at a low compression, and allowing smooth mass production by a high productive tabletting apparatus such as a rotary tabletting machine due to a high content of Isomalt in tablets. SOLUTION: The tablets with a hardness of 40 N or over and rapid disintegration within 20 seconds can be provided by compression molding a mixture containing Isomalt as a main ingredient in the tablets and further added with an active ingredient and a disintegrator at an appropriate ratio by a rotary tabletting machine. For example, a formulation of 88 wt.% of Isomal, 2 wt.% of croscarmellose sodium and 10 wt.% of crystalline cellulose gives tablet with a disintegration time of 20 seconds or less and a hardness of 40 N or over. Furthermore, a smooth production of tablets can be carried out by a rotary tableting machine even if the ratio of an essential lubricant is 0.125 wt.% in dry tableting process such as magnesium stearate. COPYRIGHT: (C)2008,JPO&INPIT
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