COMPOSITIONS AND METHODS FOR MODULATION OF NEK2 KINASE ACTIVITY

摘要

Described are serine and threonine-containing peptides derived from the proteins c-NAPl and NEK2 that constitute phosphorylation substrates for the serine/threonine kinase NEK2. These peptides can be used to measure kinase activity of a NEK2 protein and to identify compounds that modulate phosphorylation of a NEK2 substrate by a NEK2 protein. The peptides can also be used as competitive inhibitors of NEK2 kinase activity.