ASYMMETRIC ESTERIFICATION REACTION OF N-PROTECTED AMINO ALCOHOL COMPOUND USING OPTICALLY ACTIVE BISOXAZOLINE-COPPER COMPLEX AS ASYMMETRIC CATALYST

摘要

PROBLEM TO BE SOLVED: To provide a highly stereoselective method for producing an optically active N-protected amino alcohol compound useful as an intermediate for chiral medicines. SOLUTION: The invention provides a method for producing an optically active 1,3-diol monoester compound by reacting a 1,3-diol compound with an acid halide in the presence of an optically active bisoxazoline, a copper salt and an inorganic base, and a method for producing an optically active aminoethyl ester compound and an optically active amino ethanol compound by reacting an amino ethanol compound with an acid halide compound in the presence of an optically active bisoxazoline and a copper salt. COPYRIGHT: (C)2008,JPO&INPIT