3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS

摘要

Disclosed are novel cyclobutenedione Compounds 1 to 18 comprising a cyclobutenedione ring, a substituted phenyl ring, and a -CH(C₂H₅)-furan moiety. The phenyl ring and the -CH(C₂H₅)-furan moiety are each bound to the cyclobutenedione ring through a -NH- moiety. Also disclosed are methods of treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma) using the novel Compounds 1 to 18.