发明名称 |
BRIDGED BICYCLIC SERINE PROTEASE INHIBITORS |
摘要 |
<p>The present invention relates to peptidomimetic compounds which inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The compounds of this invention have a bridged bicyclic moiety at the P2 position. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.</p> |
申请公布号 |
EP1404704(B9) |
申请公布日期 |
2008.02.20 |
申请号 |
EP20020749965 |
申请日期 |
2002.07.11 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
FARMER, LUC;PITLIK, JANOS;PERNI, ROBERT;COURTNEY, LAWRENCE;VAN DRIE, JOHN |
分类号 |
A61K45/00;C07K5/10;A61K31/13;A61K31/7052;A61K38/00;A61K38/21;A61P31/12;A61P31/14;A61P43/00;C07D453/06;C07D471/08;C07K5/103;C07K5/107;C07K5/11;C07K5/117;C07K7/02;C07K7/06 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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