发明名称 |
Cellular antanonist |
摘要 |
<p>A method for identifying a compound that modifies the cellular distribution of a GPCR in a population of cells comprising:
a) taking a population of cells expressing a GPCR
b) incubating said cells with a candidate compound and with a ligand of the GPCR
c) determining distribution of said GPCR in cells treated according to step b) and comparing with distribution of GPCR in cells incubated with a ligand of the GPCR in the absence of the candidate compound;
wherein altered distribution in cells incubated with the candidate compound is indicative that the candidate compound modifies GPCR cellular distribution.</p> |
申请公布号 |
EP1865320(A3) |
申请公布日期 |
2008.02.20 |
申请号 |
EP20070252322 |
申请日期 |
2007.06.08 |
申请人 |
INSTITUT PASTEUR KOREA |
发明人 |
EMANS, NEIL;ALTSCHULER, YORAM;KWON, YONGJUN |
分类号 |
G01N33/50;C07K14/705;G01N33/74 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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