发明名称 |
Devices and methods for the production of particles |
摘要 |
The present invention provides methods and devices for producing particles with an average diameter less than about 15 mum using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5x10<SUP>9 </SUP>W/m<SUP>3 </SUP>enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.
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申请公布号 |
US7332111(B2) |
申请公布日期 |
2008.02.19 |
申请号 |
US20040483194 |
申请日期 |
2004.09.13 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
GROTHE WILLY;JARMER DANIEL;LENGSFELD CORINNE;RANDOLPH THEODORE |
分类号 |
B29B9/00;B01D11/04;B01F5/00;B01J2/04 |
主分类号 |
B29B9/00 |
代理机构 |
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