发明名称 |
Group A streptococcal polysaccharide immunogenic compositions and methods |
摘要 |
This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A polysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, the group A polysaccharides may be associated with an adjuvant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at risk of contracting group A Streptococcal infections and disease namely adults, pregnant women and in particular infants and children.
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申请公布号 |
US7332173(B2) |
申请公布日期 |
2008.02.19 |
申请号 |
US20050086214 |
申请日期 |
2005.03.21 |
申请人 |
THE ROCKEFELLER UNIVERSITY;BAXTER INTERNATIONAL INC. |
发明人 |
BLAKE MILAN S.;ZABRISKIE JOHN B.;TAI JOSEPH Y.;MICHON FRANCIS |
分类号 |
A61K39/02;A61K9/127;A61K38/00;A61K39/00;A61K39/09;A61K39/385;A61P31/04;C07H1/00 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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