发明名称 |
INTERFERON INDUZIERENDE GENETISCH VERÄNDERTE ATTENUIERTE VIREN |
摘要 |
<p>The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can be utilized to engineer site specific mutations into one or more noncoding regions of the viral genome which result in the down-regulation of one or more viral genes. Alternatively, recombinant DNA techniques can be used to engineer a mutation, including but not limited to an insertion, deletion, or substitution of an amino acid residue(s) or an epitope(s) into a coding region of the viral genome so that altered or chimeric viral proteins are expressed by the engineered virus.</p> |
申请公布号 |
AT384126(T) |
申请公布日期 |
2008.02.15 |
申请号 |
AT19990927440T |
申请日期 |
1999.06.11 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK;EGOROV, ANDREJ Y., DR.;MUSTER, THOMAS |
发明人 |
EGOROV, ANDREJ Y.;MUSTER, THOMAS;GARCIA-SASTRE, ADOLFO;PALESE, PETER;BRANDT, SABINE |
分类号 |
C12N7/01;C12N15/09;A61K35/76;A61K39/12;A61K39/145;A61K39/295;A61P31/16;C07K14/11;C12N7/00;C12N7/04;C12N15/86 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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