TRICYCLIC 6-ALKYLIDENE-PENEMS AS CLASS-D BETA-LACTAMASES INHIBITORS.

摘要

This invention relates to certain tricyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. ????-Lactamases hydrolyze ????-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with ????-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of formula I which are useful for treatment of bacterial infections having class-D enzymes associated therewith (Formula I): wherein: One of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S or O.