VERFAHREN ZUR KONTINUIERLICHEN HERSTELLUNG VON SUBSTITUIERTEN OXAZOLEN
摘要
<p>Continuous production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. Continuous production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 degrees C in the presence of an auxiliary agent and withdrawing the product from the reactor. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II); (4) converting (II) to (I) as above; (5) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (6) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.</p>
申请公布号
AT384706(T)
申请公布日期
2008.02.15
申请号
AT20020016707T
申请日期
2002.07.26
申请人
BASF AKTIENGESELLSCHAFT
发明人
RUST, HARALD;BURKART, KIRSTEN;FAUST, TILLMANN;HENKELMANN, JOCHEM;KINDLER, ALOIS;KNOLL, CHRISTIAN;MOHRY, ANDRE