| 摘要 |
PROBLEM TO BE SOLVED: To provide a process for producing a nucleoside compound, which comprises a step of reacting pentose-1-phosphoric acid with a nucleic acid base or a nucleic acid base analogue in the presence of nucleoside phosphorylase activity, which gives a nucleoside compound at an improved conversion, and which has wide applicability. SOLUTION: A salt slightly soluble in water is used as a salt of a metal cation, when producing the nucleoside compound by reacting the pentose-1-phosphoric acid with the nucleic acid base or the nucleic acid base analogue in the presence of the nucleoside phosphorylase activity, and in the presence of the salt of the metal cation forming a slightly water-soluble salt with a phosphate ion without regulating the pH. COPYRIGHT: (C)2008,JPO&INPIT
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