Compounds

摘要

The present invention relates to compounds of the general formula I wherein X, Y, Z, A, Ar, R¹, R², R³, and R⁴ are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.