发明名称 |
HERSTELLUNG VON ALPHA -HYDROXY-CARBOXY SÄURE MIT HILFE VON EINEM GEKOPPELTEN ENZYM SYSTEM |
摘要 |
<p>An economical and expedient method is disclosed for the preparation of alpha-hydroxy-carboxylic acids or salts thereof in very high enantiomeric purity which comprises oxidizing a corresponding alpha-amino-carboxylic acid or salt thereof using an amino acid deaminase followed by reducing the corresponding alpha-keto-carboxylic acid or salt produced using a D- or L-lactate dehydrogenase in the combination with an electron donor and an enzyme/substrate system for recycling the electron donor. The resulting alpha-hydroxy-carboxylic acids, hydrates, and salts thereof are valuable components and intermediates in the preparation of chiral compounds, especially pharmaceuticals. This invention also relates to the use of alpha-amino-carboxylic acids, hydrates, and salts thereof and a coupled enzyme system in the production of alpha-hydroxy-carboxylic acids, hydrates, and salts thereof.</p> |
申请公布号 |
DE60128581(T2) |
申请公布日期 |
2008.02.14 |
申请号 |
DE2001628581T |
申请日期 |
2001.10.17 |
申请人 |
EXCELSYN MOLECULAR DEVELPOPMENT LTD. |
发明人 |
SENKPEIL, RICHARD F.;PANTALEONE, DAVID P.;TAYLOR, PAUL P. |
分类号 |
C12P7/42;C12P41/00;C07D209/18;C07D209/20;C07D213/55;C07D213/68;C07D233/26;C07D333/60;C12N15/52;C12R1/91 |
主分类号 |
C12P7/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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