EP4 receptor antagonists

摘要

Compounds of formula (I): wherein: R² is H or an optionally substituted C_1-4 alkyl group; Y is either -(CH₂)_n-X-, where n is 1 or 2 and X is O, S, S(-O), S(-O)₂, or NR^N1, where R^N1 is selected from H or optionally substituted C_1-4 alkyl, or Y is -C(-O)NR^N2-, where R^N2 is selected from H, and optionally substituted C_1-7 alkyl or C_5-20 aryl; R³ is an optionally substituted C₆ aryl group linked to a further optionally substituted C₆ aryl group, wherein if both C₆ aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C_1-3 alkylene group; and R⁵ is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C_1-7 alkyl, C_5-20 aryl or NR^N3R^N4, where R^N3 and R^N4 are independently selected from optionally substituted C_1-4 alkyl; (iv) tetrazol-5-yl.