| 摘要 |
<p>The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, -0-, or -CH<SUB>2</SUB>-; m and n vary independently and are an integer from 1 to 15; p and q vary from 0 to an integer from 1 to 4; B is a single bond or -CR<SUP>3</SUP>R<SUP>4</SUP>; D is formula (2): or formula (3): and X is halogen; R<SUP>1</SUP> to R<SUP>4</SUP> are various substituents selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokinetics of compounds of Formula 1; and R<SUP>1</SUP> and R<SUP>2</SUP> or R<SUP>3</SUP> and R<SUP>4</SUP> may optionally be tethered together to form a 3- to 7-membered alicyclic ring. These compounds are useful for the treatment of various infections, metabolic, cardiovascular and neurological disorders.</p> |
