EXTERNAL PREPARATION COMPRISING PROSTAGLANDIN DERIVATIVE

摘要

An external preparation comprising a complex comprising a prostaglandin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt and cyclodextrin. (I) wherein R represents a group represented by the formula: -(CH<SUB>2</SUB>)<SUB>4</SUB>-S-CH<SUB>2</SUB>-CO<SUB>2</SUB>H, -(CH<SUB>2</SUB>)<SUB>4</SUB>-S-CH<SUB>2</SUB>-CO<SUB>2</SUB>CH<SUB>3</SUB>, -(CH<SUB>2</SUB>)<SUB>4</SUB>-C=C-CO<SUB>2</SUB>H, -CH<SUB>2</SUB>-S-(CH<SUB>2</SUB>)<SUB>2</SUB>-S-CH<SUB>2</SUB>-CO<SUB>2</SUB>H or -CH<SUB>2</SUB>-S-(CH<SUB>2</SUB>)<SUB>4</SUB>-CO<SUB>2</SUB>H. The external preparation ensures the storage stability and the content uniformity of the compound of the formula (I).