DETECTING AND TREATING DEMENTIA

摘要

This document relates to methods and materials for detecting mutations th at can be linked to dementia. For example, methods and materials for detecti ng one or more mutations within PGRN nucleic acid are provided. This documen t also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mam mals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.