PYRIDINE DERIVATIVES AS SODIUM CHANNEL BLOCKERS

摘要

Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein; each of R<SUP>1</SUP> to R<SUP>4</SUP> is independently selected from hydrogen and C<SUB>1-4</SUB> alkyl, and each of rings A and B independently is optionally further substituted by up to three substituents, each of which is independently selected from the group consisting of halogen, hydroxy, C<SUB>1-4</SUB> aIkoxy, C<SUB>1-4</SUB> alkyl, C<SUB>1-5</SUB>alkanoyl, CF<SUB>3</SUB>, CF<SUB>3</SUB>O and cyano; with the proviso that ring A must contain at least one CF<SUB>3</SUB>group, are useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.