A BIODEGRADABLE POLYESTER CONTAINING PHOSPHATIDYLCHOLINE GROUPS AND ITS PREPARATION

摘要

A biodegradable polyester containing phosphatidylcholine groups, its main chain is biodegradable polyester, the phosphatidylcholine groups are positioned on the end groups and side chains of polyester main chain or on the side chains of polyester main chain. Its preparation method includes the following steps: (1) use phosphatidylcholine containing two hydroxyl groups to ring-open cyclic esters (lactide) so as to obtain biodegradable polyester whose single side-chain contains phosphatidylcholine group; then said polyester can be used for preparing biodegradable polyester whose multi side-chains contain phosphatidylcholine groups by adding diisocyanate and chain extender; and (2) use the above-mentioned prepared biodegradable polyester whose single side-chain or multi side-chains contain(s) phosphatidylcholine group(s) to react with 2-chloro-2-oxo-1,3,2-dioxaphosphacyclopentane to obtain intermediate compound, then use trimethylamine to ring-open said obtained intermediate so as to obtain a biodegradable polyester whose end groups and single side-chain or multi side-chains contain phosphatidylcholine groups. These biodegradable polyesters can be used as biodegradable materials, especially medicaments sustained-releasing materials and tissue engineering materials.