发明名称 |
COMPOSITIONS AND METHODS FOR INDUCING THE ACTIVATION OF IMMATURE MONOCYTIC DENDRITIC CELLS |
摘要 |
The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamma, to induce a Th-I and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populations useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided. |
申请公布号 |
WO2007067782(A3) |
申请公布日期 |
2008.02.14 |
申请号 |
WO2006US47083 |
申请日期 |
2006.12.08 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC.;BOYNTON, ALTON L.;BOSCH, MARNIX L. |
发明人 |
BOYNTON, ALTON L.;BOSCH, MARNIX L. |
分类号 |
C12N5/00;C12N5/0784 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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