Dna Pkinase Inhibitors For Treating Cancer And Diabetes

摘要

Methods of treating disorders associated with the PKB signalling pathway, such as cancer, diabetes, and neurodegenerative disorders, are provided. The methods comprise modulating the activity of DNA-PK; this enzyme has been identified as having serine 473 kinase activity. Compositions comprising DNA-PK or modulators thereof are also provided for use in such methods.