Trojan horse immunotherapy

摘要

The present invention provides methods for the delivery of therapeutic proteins to an area of inflammation and neuronal damage within the central nervous system (CNS). In this invention, immunocytes that can cross the blood brain barrier and access sites of CNS injury/inflammation, are genetically engineered to express and secrete a therapeutic protein of interest and are transplanted into a subject having a CNS injury. These genetically modified "carrier immunocytes" home to the site of a CNS lesion and secret the therapeutic agent, thereby ameliorating disease symptoms and pathology.