发明名称 |
Synthesis and Application of Procainamide Analogs for Use in an Immunoassay |
摘要 |
The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.
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申请公布号 |
US2008039656(A1) |
申请公布日期 |
2008.02.14 |
申请号 |
US20070846327 |
申请日期 |
2007.08.28 |
申请人 |
DADE BEHRING INC. |
发明人 |
CHU VICTOR P.;TENG ZHU;GOSS STEVE P.;EDWARDS RONALD L.;GARVEY KELLE M.;GORZYNSKI TIMOTHY J.;BEDZYK WILLIAM D. |
分类号 |
C07C233/64;C07C231/02;C07C237/34;C07K14/47;G01N33/53;G01N33/566 |
主分类号 |
C07C233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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