摘要 |
<p>It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3- propanediol, and L-(+)-a-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3- propanediol, and L-(+)-a-phenylglycinol salts.</p> |
申请人 |
ESTEVE QUIMICA, S. A.;GASANZ GUILLEN, YOLANDA;MONTSALVATJE LLAGOSTERA, MONTSERRAT;TALAVERA ESCASANY, PEDRO |
发明人 |
GASANZ GUILLEN, YOLANDA;MONTSALVATJE LLAGOSTERA, MONTSERRAT;TALAVERA ESCASANY, PEDRO |