发明名称 |
AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE |
摘要 |
<p>Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).</p> |
申请公布号 |
WO2008017161(A1) |
申请公布日期 |
2008.02.14 |
申请号 |
WO2007CA01396 |
申请日期 |
2007.08.09 |
申请人 |
RAMTOHUL, YEEMAN K.;MERCK FROSST CANADA LTD. |
发明人 |
RAMTOHUL, YEEMAN K. |
分类号 |
A61K31/519;C07D473/34;A61K31/52;A61K31/522;A61P3/04;A61P3/06;A61P3/10;C07D473/16;C07D473/18;C07D473/32;C07D513/04 |
主分类号 |
A61K31/519 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|