| 摘要 |
A solid preparation of enteric solid dispersion is provided to inhibit damage of solid preparation dissolution properties and rapidly release a drug in the solid preparation by using a specific disintegrant. A solid preparation of enteric solid dispersion comprises a poorly soluble drug, an enteric polymer and a disintegrant that is low substituted hydroxypropylcellulose having an average diameter of 10-100 mum and specific surface area of 1.0 m^2/g measured by BET(Brunauer, Emmett and Teller) method, wherein the enteric polymer is selected from cellulose acetate phthalate, cellulose acetate trimellitate, cellulose acetate succinate, methylcellulose phthalate, hydroxymethylcellulose ethyl phthalate, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, hydroxypropylmethylacetate maleate, hydroxypropylmethyltrimaleate, carboxymethylethylcellulose, polyvinylbutylate phthalate, polyvinylalcohol acetate phthalate, methacrylic acid/ethyl acrylate copolymer, methacrylic acid/methacrylic acid methyl copolymer and methacrylic acid copolymer; and the solid preparation is prepared by spraying enteric polymer solution dispersing the poorly soluble drug to the low substituted hydroxypropylcellulose powder, and assembling and drying the mixture.
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