发明名称 |
Solid dosage form comprising solid dispersion and method for producing the same |
摘要 |
<p>Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µ m and a specific surface area measured by BET method of at least 1.0 m 2 /g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 µm and a specific surface area measured by BET method of at least 1.0 m 2 /g and serving as a disintegrant and granulating the resultant; and drying.</p> |
申请公布号 |
EP1886672(A2) |
申请公布日期 |
2008.02.13 |
申请号 |
EP20070015395 |
申请日期 |
2007.08.06 |
申请人 |
SHIN-ETSU CHEMICAL CO., LTD. |
发明人 |
KUSAKI, FUMIE;HOSHINO, TAKAFUMI;MARUYAMA, NAOSUKE;NISHIYAMA, YUICHI;FUKUI, IKUO;UMEZAWA, HIROSHI |
分类号 |
A61K9/20;A61K31/44;A61K47/38 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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