| 摘要 |
<p>Producing a composite made of oligonucleotides or polynucleotides and hydrophobic biodegradable polymers comprises producing an aqueous solution of a polyethylene glycol having a mean molecular weight of 600-8,000 g/mole. Producing a composite made of oligonucleotides or polynucleotides and hydrophobic biodegradable polymers comprises: (i) producing an aqueous solution of a polyethylene glycol having a mean molecular weight of 600-8,000 g/mole; (ii) adding an aqueous, possibly buffered, solution of oligonucleotides or polynucleotides to the aqueous solution from step (i); (iii) freezing the aqueous solution from step (ii) and subsequently freeze-drying the frozen solution to obtain a freeze-dried substrate; (iv) providing a solution of the hydrophobic biodegradable polymer in an organic solvent; (v) adding the substrate obtained according to step (iii) to the solution of the polymer; and (vi) removing the organic solvent to obtain the composite. An independent claim is a composite, used as a coating material for a medical implant or as a filler of a cavity of a medical implant, the composite produced according to a method above.</p> |
