发明名称 |
IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA |
摘要 |
<p>#CMT# #/CMT# An isolated JAK2 (Janus kinase 2) protein is a mutation of the amino acid 617, and especially mutation V617F, with its sequence present in SEQ ID No. 1, or a similar sequence in other mammals, is new. The nucleotide sequence coding for the variant JAK2 V617F is especially SEQ ID No 2 possessing the t/g mutation in position 1849 from the ATG marking the start of the transcription. #CMT#USE : #/CMT# Diagnosis of myeloproliferative syndromes related to variant JAK2 V617F. #CMT#ADVANTAGE : #/CMT# The identification of the protein allows specific inhibitors to be produced. #CMT#DESCRIPTION OF DRAWINGS : #/CMT# The drawing is a diagram showing the key role of JAK2 in Vaquez-type polyglobulia. (Drawing contains non-English language text).</p> |
申请公布号 |
EP1692281(B8) |
申请公布日期 |
2008.02.13 |
申请号 |
EP20050815749 |
申请日期 |
2005.10.26 |
申请人 |
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);INSTITUT GUSTAVE ROUSSY;UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES;UNIVERSITE PARIS SUD |
发明人 |
VAINCHENKER, WILLIAM;UGO, VALERIE;JAMES, CHLOE;LE COUEDIC, JEAN-PIERRE;CASADEVALL, NICOLE |
分类号 |
C12N9/12;C12Q1/68;G01N33/53 |
主分类号 |
C12N9/12 |
代理机构 |
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