发明名称 |
ANTI-CD3 AND ANTIGEN-SPECIFIC IMMUNOTHERAPY TO TREAT AUTOIMMUNITY |
摘要 |
The invention provides methods for treating autoimmunity and for reestablishing tolerance. The methods involve the coadministration of anti-CD3 antibodies and self-antigens. The coadministration has the potential to provide a synergistic effect of protecting or reducing autoaggressive immune processes and/or of reestablishing tolerance towards self-antigens. An underlying rationale behind the methods is that the administration of self-antigens together with anti-CD3 antibodies can alter the response to those self-antigens and prevent progression of autoimmunity. By rechallenging with the autoantigens and stimulating the non-pathogenic response, the blockade of the autoimmune process can be maintained. Preclinical evidence provided herein shows that the combination of anti-CD3 and autoantigen is synergistic in reversing autoimmune diabetes, and therefore, suggests that combination therapy of anti-CD3 and self-antigen may provide synergistic protection in reversing other autoimmune disorders. |
申请公布号 |
EP1725254(A4) |
申请公布日期 |
2008.02.13 |
申请号 |
EP20050722771 |
申请日期 |
2005.02.04 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;LAJOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY;UCSF DIABETES CENTER |
发明人 |
HEROLD, KEVAN;VON HERRATH, MATHIAS;BLUESTONE, JEFFREY, A. |
分类号 |
A61K39/00;A61K39/38;A61K39/395;C07K16/28 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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