| 发明名称 |
USE OF LIPOXIN COMPOUNDS FOR INHIBITING OF TNF-(ALPHA) INITIATED NEUTROPHIL RESPONSE |
| 摘要 |
The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF.alpha.)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNF.alpha.-stimulated superoxide anion generation and IL-1.beta. release by human PMN.
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| 申请公布号 |
CA2367909(C) |
申请公布日期 |
2008.02.12 |
| 申请号 |
CA20002367909 |
申请日期 |
2000.03.14 |
| 申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
SERHAN, CHARLES N. |
| 分类号 |
A61K31/232;A61P17/00;A61K31/202;A61K31/23;A61K31/557;A61P17/06;A61P17/08;A61P29/00;A61P43/00 |
主分类号 |
A61K31/232 |
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