发明名称 |
Methods for increasing protein polyethylene glycol (PEG) conjugation |
摘要 |
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.
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申请公布号 |
US7329516(B2) |
申请公布日期 |
2008.02.12 |
申请号 |
US20050077897 |
申请日期 |
2005.03.11 |
申请人 |
ANTICANCER, INC. |
发明人 |
LI SHUKUAN;YANG ZHIJIAN;SUN XINGHUA;TAN YUYING;YAGI SHIGEO |
分类号 |
C12N9/96;A61K38/17;A61K38/51;A61K47/48;C07K1/107;C07K14/21;C08G63/48;C08G63/91;C12N9/88 |
主分类号 |
C12N9/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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