发明名称 |
GENETICALLY MODIFIED MICROORGANISM AND PROCESS FOR PRODUCTION OF MACROLIDE COMPOUND USING THE MICROORGANISM |
摘要 |
A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium. |
申请公布号 |
KR20080012845(A) |
申请公布日期 |
2008.02.12 |
申请号 |
KR20077024481 |
申请日期 |
2007.10.24 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD.;MERCIAN CORPORATION |
发明人 |
MACHIDA KAZUHIRO;ARITOKU YASUHIDE |
分类号 |
C12N15/09;C12N1/21;C12P17/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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