发明名称 |
A METHOD FOR MASS PRODUCTION OF FK506 BY FKBR1 GENE ENCODING FK520 TRANSCRIPTION REGULATOR FROM STREPTOMYCES SP |
摘要 |
A method for mass-producing FK506(tacrolimus) using a fkbR1 introduced strain is provided to increase the production amount of the FK506 about 3 times higher than a mother strain, thereby being very useful for biological medicine industry. A method for mass-producing FK506(tacrolimus) comprises the steps of: (a) transforming a host cell using a recombinant DNA where a fkbR1 as a gene encoding a biosynthesis controlling enzyme of FK520(ascomycin) derived from Streptomyces hygroscopicus var. ascomyceticus ATCC 14891 strain is introduced; and (b) culturing the host cell.
|
申请公布号 |
KR100800222(B1) |
申请公布日期 |
2008.02.01 |
申请号 |
KR20070011445 |
申请日期 |
2007.02.05 |
申请人 |
MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION |
发明人 |
SUH, JOO WON;JIN, YING YU;KWON, HYUNG JIN;SHIN, SU KYOUNG |
分类号 |
C12N15/63;C12N1/20;C12N15/09;C12N15/76 |
主分类号 |
C12N15/63 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|