发明名称 |
THERAPEUTIC AGENT FOR MALIGNANT MESOTHELIOMA |
摘要 |
<p>Disclosed is a therapeutic agent effective for malignant mesothelioma. Specifically disclosed is a therapeutic agent for mesothelioma, which comprises a calponin-targeting oncolytic herpes simplex virus (HSV-1) mutant, preferably strain d12.CALPf?RR. Also disclosed is a method for producing a cell for use in the treatment of mesothelioma, which is characterized by infecting a mesothelioma cell removed from a patient with a herpes simplex virus F-type mutant which can proliferate in a calponin gene-targeting manner, preferably strain d12.CALPf?RR. Further disclosed are: a cell produced by the method; and a calponin-targeting oncolytic herpes simplex virus (HSV-1) mutant, preferably strain d12.CALPf?RR.</p> |
申请公布号 |
WO2008013276(A1) |
申请公布日期 |
2008.01.31 |
申请号 |
WO2007JP64798 |
申请日期 |
2007.07.27 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY;TAKAHASHI, KATSUHITO;YAMAMURA, HISAKO |
发明人 |
TAKAHASHI, KATSUHITO;YAMAMURA, HISAKO |
分类号 |
C12N7/00;A61K35/12;A61K35/76;A61P35/00;C12N5/10;C12R1/93 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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