INHIBITION OF MARCKS-MEDIATED DEGRANULATION BY MARCKS N-TERMINAL PEPTIDES IN TREATING INFLAMMATION

摘要

The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. Peptide fragments and variants thereof of MANS peptide as disclosed in the present invention are useful in such methods. The present invention also discloses MARCKS protein and the inhibition of MARCKS-mediated degranulation to prevent release of inflammatory mediators by N-terminal peptides of MARCKS.