发明名称 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE |
摘要 |
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells. |
申请公布号 |
WO2008012828(A2) |
申请公布日期 |
2008.01.31 |
申请号 |
WO2007IL00946 |
申请日期 |
2007.07.29 |
申请人 |
COLBAR LIFESCIENCE LTD.;ZUBERY, YUVAL;GOLDLUST, ARIE;BAYER, THOMAS;NIR, ERAN |
发明人 |
ZUBERY, YUVAL;GOLDLUST, ARIE;BAYER, THOMAS;NIR, ERAN |
分类号 |
A61F2/00;A61K38/00;A61P19/00 |
主分类号 |
A61F2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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